The Dutch Kidney Foundation (DKF) decided to financially support the project "Renal energy crisis in sepsis-associated kidney injury: relevance and therapeutic opportunities of sustaining renal mitochondrial function" with a Kolff Grant awarded to Hjalmar Bouma. Acute kidney injury (AKI) is most frequently caused by sepsis, which is the leading cause of death among patients on the intensive care unit (ICU). The occurrence of renal dysfunction is a very strong risk factor for mortality and is associated with a threefold higher mortality rate during sepsis. In this project, we aim to prevent acute kidney injury in sepsis by preserving mitochondrial function, and explore the effects of mitochondrial damage on renal function and survival after sepsis. The project is intended to start on April 1, 2017 and will last 4 years.