Machine-learning to predict in-hospital sepsis mortality
Time is of the essence in the treatment of sepsis; early and aggressive treatment is important to reduce mortality as indicated in recent studies. In 30-50% of patients, sepsis treatment is initiated in the emergency department (ED). Sepsis is responsible for 2% of hospitalizations and 17% of in-hospital deaths. Worldwide around 1400 patients die as a result of sepsis every day and the incidence of sepsis increases annually. Despite treatment, over 20% of the patients with sepsis deteriorate during their first 48 hours in the hospital. Deterioration can result in mortality and/or morbidity, including shock or (multiple) organ failure, when not promptly responded to. Some small studies, mainly in the ICU and general ward population, have shown that patient deterioration was preceded by changes in vital signs in over 80% of the cases, often hours before the deterioration was actually clinically noticed. However, this has not yet been investigated in the ED population of patients presenting with sepsis.